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Calcium-channel Blockers

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Calcium-channel blockers (sometimes called calcium antagonists) are a group of medicines that affect the way calcium passes into certain muscle cells. They are used to treat various conditions including high blood pressure, angina, Raynaud's phenomenon (see below), and some abnormal heart rhythms (arrhythmias).
A calcium-channel blocker can be used alone. However, one is often combined with another medicine to treat high blood pressure or angina when one medicine alone has not worked so well.

The heart is mainly made of special muscle cells which contract to pump blood into the blood vessels (arteries). The walls of the arteries also contain 'smooth' muscle cells. When these contract, the artery narrows. The heart muscle cells and smooth muscle cells need calcium to contract. Calcium passes into these cells via tiny 'channels'.

Calcium-channel blockers reduce the amount of calcium that goes into these muscle cells. This causes these muscle cells to relax. So, the effects of these medicines are:
  • To widen the arteries, which:
    • Reduces the blood pressure.
    • Helps to ease angina by widening the coronary arteries.
    • Can ease symptoms of Raynaud's phenomenon. In this condition you have cold and painful fingers and toes caused by narrowing of the arteries in the hands and feet.

  • To reduce the force and rate of the heartbeat. This helps to prevent angina pains.
Different types of calcium-channel blockers differ in their main sites of action in the body. Therefore, different types are used for different conditions.

Most people who take calcium-channel blockers have no side-effects, or only minor ones. Because of their action to relax and widen blood vessels (arteries), some people develop flushing and headache. These tend to ease over a few days if you continue to take the tablets. Mild ankle swelling is also quite common, particularly with dihydropyridine calcium-channel blockers.
Constipation is quite a common side-effect, especially with verapamil. You can often deal with this by increasing the amount of fibre that you eat, and increasing the amount of water and other fluids that you drink.
Other side-effects are uncommon and include feeling sick, palpitations, tiredness, dizziness, and rashes. This is not a complete list of all possible known side-effects. Read the information leaflet that comes with your particular brand for a full list of possible side-effects, but be optimistic - don't necessarily be put off taking these tablets. Serious side-effects are rare, and it's wise not to stop calcium-channel blockers without speaking to your doctor.
Some people who suddenly stop taking a calcium-channel blocker have a 'rebound' flare-up of angina. Therefore, it is best not to stop taking these medicines without first consulting a doctor.
If you are taking a calcium-channel blocker, do not drink grapefruit juice. This can interact with the medicine and alter its effect.
If you think you have had a side-effect to one of your medicines you can report this on the Yellow Card Scheme. You can do this online at the following web address: www.mhra.gov.uk/yellowcard.
The Yellow Card Scheme is used to make pharmacists, doctors and nurses aware of any new side-effects that medicines may have caused. If you wish to report a side-effect, you will need to provide basic information about:
  • The side-effect.
  • The name of the medicine which you think caused it.
  • Information about the person who had the side-effect.
  • Your contact details as the reporter of the side-effect.
It is helpful if you have your medication - and/or the leaflet that came with it - with you while you fill out the report.

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